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KMID : 0923620200200030020
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Immune Network
2020 Volume.20 No. 3 p.20 ~ p.20
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The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches
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Choi Han-Byeul
Song Heon-Ju
Jung Yong-Woo
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Abstract
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Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naive to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.
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KEYWORD
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CD8-positive T-lymphocytes, Immunologic memory, Receptors, CCR7, Cell movement, Chemotaxis, Immunotherapy
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